Journal: Current Nutrition Reports

Article Title: Maternal Intake of Probiotics to Program Offspring Health

doi: 10.1007/s13668-022-00429-w

Figure Lengend Snippet: Pre-clinical studies evaluating probiotic administration starting before or during gestation on offspring outcomes

Article Snippet: , SPF C57BL/6 mice ± probiotics Dams n = 10/group Offspring n = 8–10/group/time point (male and female) , Akkermansia muciniphila MucT (ATCC BAA-835) 1 × 10 8 –10 9 CFU/day by gavage GD1–3 days before birth; PND3–PND21 , Until PND42 : No effect on body weight or intestinal tissue development , Dams No effect during pregnancy PND21 : ↑ A. muciniphila , Ruminococcus _1, ↓ Coriobacteriaceae UCG-002, Lachnospiraceae UCG-001, Ruminiclostridium Offspring No effect on A. muciniphila abundance or ⍺-diversity PND42 : Change in β-diversity, ↓ Dubosiella , Lachnospiraceae _UCG_001, Parasutterella , ↑ Gordonibacter , Lachnospiraceae _UCG_006, Prevotellaceae _UCG_001; ↑ the D-glutamine and D-glutamate microbial metabolism pathway , [ ] .

Techniques: Animal Model, Control, Probiotics, Infection, Mouse Assay, Clinical Proteomics, Bacteria, Activity Assay, Expressing, Activation Assay, Concentration Assay, Gene Expression, Permeability, Injection

Journal: Current Nutrition Reports

Article Title: Maternal Intake of Probiotics to Program Offspring Health

doi: 10.1007/s13668-022-00429-w

Figure Lengend Snippet: Clinical studies evaluating probiotic administration starting before and during gestation on offspring outcomes

Article Snippet: , SPF C57BL/6 mice ± probiotics Dams n = 10/group Offspring n = 8–10/group/time point (male and female) , Akkermansia muciniphila MucT (ATCC BAA-835) 1 × 10 8 –10 9 CFU/day by gavage GD1–3 days before birth; PND3–PND21 , Until PND42 : No effect on body weight or intestinal tissue development , Dams No effect during pregnancy PND21 : ↑ A. muciniphila , Ruminococcus _1, ↓ Coriobacteriaceae UCG-002, Lachnospiraceae UCG-001, Ruminiclostridium Offspring No effect on A. muciniphila abundance or ⍺-diversity PND42 : Change in β-diversity, ↓ Dubosiella , Lachnospiraceae _UCG_001, Parasutterella , ↑ Gordonibacter , Lachnospiraceae _UCG_006, Prevotellaceae _UCG_001; ↑ the D-glutamine and D-glutamate microbial metabolism pathway , [ ] .

Techniques: Control, Capsules, Probiotics, Methylation, DNA Methylation Assay, Biomarker Discovery

Journal: Current Nutrition Reports

Article Title: Maternal Intake of Probiotics to Program Offspring Health

doi: 10.1007/s13668-022-00429-w

Figure Lengend Snippet: Offspring health outcomes programmed by maternal probiotic intake started prenatally. Previous knowledge (until 2017) included growth, gut health and intestinal barrier, allergic diseases, and gut microbiota findings. In addition to these outcomes, recent studies described effects on metabolic disorders, and neurodevelopment and anxiety. Clinical and pre-clinical findings are indicated in bold and italics, respectively. Icons depict findings assessed in infants or animal models (mice, rats, rabbits, or pigs). Created with BioRender.com

Article Snippet: , SPF C57BL/6 mice ± probiotics Dams n = 10/group Offspring n = 8–10/group/time point (male and female) , Akkermansia muciniphila MucT (ATCC BAA-835) 1 × 10 8 –10 9 CFU/day by gavage GD1–3 days before birth; PND3–PND21 , Until PND42 : No effect on body weight or intestinal tissue development , Dams No effect during pregnancy PND21 : ↑ A. muciniphila , Ruminococcus _1, ↓ Coriobacteriaceae UCG-002, Lachnospiraceae UCG-001, Ruminiclostridium Offspring No effect on A. muciniphila abundance or ⍺-diversity PND42 : Change in β-diversity, ↓ Dubosiella , Lachnospiraceae _UCG_001, Parasutterella , ↑ Gordonibacter , Lachnospiraceae _UCG_006, Prevotellaceae _UCG_001; ↑ the D-glutamine and D-glutamate microbial metabolism pathway , [ ] .

Techniques: